By Suzanne De La Monte
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Extra resources for Alzheimer’s Disease Pathogenesis-Core Concepts, Shifting Paradigms and Therapeutic Targets
Kaye, M. Moore, D. Waichunas, N. E. Carlson, and J. F. Quinn, 2007, Blood-brain barrier impairment in Alzheimer disease: stability and functional significance: Neurology, v. 68, no. 21, p. 1809-1814. Chen, D. , S. A. Stern, A. Garcia-Osta, B. Saunier-Rebori, G. Pollonini, D. BambahMukku, R. D. Blitzer, and C. M. Alberini, 2011, A critical role for IGF-II in memory consolidation and enhancement: Nature, v. 469, no. 7331, p. 491-497. , Y. Ji, Y. Sun, R. J. Kascsak, R. B. Kascsak, P. D. Mehta, S. M.
Consequently, oxidative stress is extensive in AD, and Aβ peptides stimulate oxidative stress by both direct and indirect mechanisms. , 2007) Aβ peptides also generate oxidative stress via neuroinflammation. , 2007). , 2000). It was demonstrated that reduced brain insulin signaling is associated with increased tau phosphorylation and Aβ levels in a Streptozotocin induced model of diabetes mellitus, and also insulin promotes the release of intracellular Aβ in neuronal cultures and accelerates Aβ trafficking to the plasma membrane.
Xuereb, T. Bak, P. Nestor, J. Knibb, K. Patterson, and J. R. Hodges, 2007, Focal cortical presentations of Alzheimer's disease: Brain, v. 130, no. Pt 10, p. 2636-2645. Baker, L. , D. J. Cross, S. Minoshima, D. Belongia, G. S. Watson, and S. , v. 68, no. 1, p. 51-57. , S. Sylvain-Roy, B. C. de, and M. C. , v. 169, p. 365375. , C. M. Lill, and R. E. Tanzi, 2010, The genetics of Alzheimer disease: back to the future: Neuron, v. 68, no. 2, p. 270-281. Bowman, G. , J. A. Kaye, M. Moore, D. Waichunas, N.