5-HT4 Receptors in the Brain and Periphery by Robin D. Clark (auth.), Richard M. Eglen Ph.D. (eds.)

By Robin D. Clark (auth.), Richard M. Eglen Ph.D. (eds.)

This e-book presents a finished, updated overview of the distribution, pharmacology and body structure of vital 5-hydroxytryptamine (5-HT)4 receptors. The 5-HT receptor subtypes convey a different pharmacology, distribution and serve as, of which the 5-HT4 receptor has been the most intensively studied in recent times, either from a simple learn viewpoint and as a objective for novel therapeutics.

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T. ~ :;. S-M':'... c. cS-K':",,. o~-tr.. ):. Fig. 2. Alignment of amino acid sequences of the available 5-HT4 receptors. Differences in the human sequences are marked in gray. 48 Cloning of 5- HT4 Receptors from Other Species More recendy, the mouse 5-HT4L receptor has been cloned from cultured collicular neurons13 using PCR amplification. The mouse sequence (Fig. 2) predicts a peptide of the identical length as the rat 5-HT4L> 406 amino acids. A high degree of homology with the rat sequence was noted, giving rise to only 14 differences between the rat and mouse amino acid sequences.

J Pharmacol Exp Ther 1996; 277:97-104. 84. Hagihara K, Hayakawa T, Arai T et al. Antagonistic activities of N3389, a newly synthesized diazabicyclo derivative, at 5-HT3 and 5-HT4 receptors. Eur J Pharmacol1994; 271:159-166. 85. Buchheit KH, Klein F, Kloppner E et al. The serotonin 5-HT4 receptor: Part 3: Design and pharmacological evaluation of a new class of antagonists. Bioorg Med Chern Lett 1995; 5:2495-2500. 86. Oxford AW. Substituted phenylcarbamates and phenylureas, their preparation and their use as 5-HT antagonists.

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